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Development of an Innovative Nanomedicine based on Vascular Targeting Delivery

Reseach Themes

1. Tumor Vascular Endothelial Cells
2. Development of an innovative delivery system targeted for liver endothelial cells

3. Development of an innovative drug delivery system targeting to endothelial cells in adipose tissue

4. Synthesis and development of new ligand for targeting disease endothelial cell specifically

(To see detailed imformation, click each research theme)

　
Blood vessels play a role as a lifeline streched in the whole body and are involved in various disease. Abnormal angiogenesis participates in tumor and hepatitis. In addition, various kinds of lifstyle disease are induced by obesity. Obesity is also highly related with angiogenesis.
Our research goal is to develop a novel drug delivery system, which can actively target to abnormal vasucular endothelial cells in lesion. Furthermore, we also aim to develop an innovative DDS, which can penetrate the vascular barrier and directly deliver the medicine to the parenchymal cells. This project is performed with collaboration with Dr. Kyoko Hida (Graduate School of Dental Medicine, Hokkaido University).